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hazards effects of biocompatibility factors on clinical outcomes are illustrated in Figure 1. These perturbations in normal membrane physiology are thought to result in impaired host defense, modifications to peritoneal structure including peritoneal fibrosis and vasculopathy, And changes in dialytic functions, Including increased solute permeability and ultrafiltration failure. the value of each of these biocompatibility factors and their hypothesized roles in cellular and membrane dysfunction has been extensively reviewed1,2,3.