Te'o, who is tied for second on the team with 17 tackles, wasn't sure when or how he got hurt.
Te'o and the team are declining to reveal much information, but club spokesman Bill Johnston said Wednesday that it's a different injury than the one Te'o suffered in the first exhibition game of his rookie season in 2013. Te'o missed the first three games of 2013 with a foot injury and had surgery in the offseason.
"But when I heard the news it was definitely frustrating and devastating for me that I couldn't be out there with my guys."
The Chargers (2-1) host Jacksonville (0-3) on Sunday.
He also had a poor showing in Notre Dame's BCS championship game loss to Alabama following the 2012 season,
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He sprained his left foot during training camp.
Coach Mike McCoy refused to be specific about Te'o's injury.
Te'o fractured his right foot Sunday in a 22-10 victory at Buffalo and is out indefinitely,
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Te'o could be out for six to 10 weeks if he needs to have a screw inserted in his foot, said Dr. Mark Drakos, who specializes in foot and ankle disorders at the Hospital for Special Surgery in New York and played wide receiver at Harvard.
"I chose to stay positive and chose to know that in a few of weeks I'll be OK. In a few weeks I'll be running around with the fellas and running around with the bros and playing high-quality football," he said.
"He'll be back on the field when he's healthy. He's week-to-week right now. He was sore after the game and after running tests on Monday we diagnosed it the way it is," the coach said.
Te'o said he's trying to keep it in perspective that other people elsewhere have more serious issues.
Te'o has settled into life in the NFL after enduring the glare of publicity following the revelation he'd gotten fooled by a hoax involving a fake girlfriend while at Notre Dame.
SAN DIEGO (AP)